Recently, based on comments to this post I decided to turn Vistas UAC back on in "silent mode" using TweakUAC. Doing so allows me to run Windows Live Mesh to support folder synchronization which I’m now using to backup my blog content. The downside is that after making this change I started getting System.Runtime.InteropServices.COMException errors when loading a large application into VS.NET 2008.
After a bit of head scratching I thought to change my VS.NET shortcut to launch with "Run as Administrator" enabled which resolved the error. Now, back to work!